2021 MLB odds, picks, best bets for May 21 from proven model: This four-way parlay pays more than 20-1

Two of baseball’s most bitter rivals collide on Friday when the San Francisco Giants and Los Angeles Dodgers open a three-game series at Oracle Park in San Francisco. The Giants (28-16) have won five in a row and own the best record in baseball. They have a two-game lead over the Dodgers (26-18), who have won four straight and sit in third in the NL West. The Dodgers are -125 money-line favorites in the latest Dodgers vs. Giants odds from William Hill Sportsbook, while the Giants are +115 underdogs. 

That is one of the marquee matchups among the 15 games on Friday’s MLB schedule. Other games include the team with the best record in the AL, the White Sox (26-16), visiting the Bronx to take on the Yankees and the top two teams in the NL Central — the Cubs and Cardinals — opening a three-game series in Chicago. Before you lock in your MLB picks on those games or any others Friday night, you need to see the MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league’s last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. It is off to a fast start in 2021, going 52-36 on top-rated MLB money-line picks through seven weeks, returning over $900. Anyone following it has seen huge rewards.

Now, the model has evaluated the latest MLB lines for Friday and posted its best bets for the evening games. Parlaying these four MLB picks would pay more than 20-1. Head to SportsLine to see the picks

Top MLB picks for Friday, May 21

The model likes the White Sox (-105) to beat the Yankees at 7:05 p.m. ET. The AL Central-leading White Sox have not dropped a series since losing two of three to Cleveland in early May. They are coming off a 2-1 win at Minnesota on Wednesday.

On Friday, Chicago takes on southpaw Jordan Montgomery (2-1, 4.75 ERA), who is coming off his worst outing of the season. Montgomery gave up his most runs (five) this season and had his shortest outing (three innings) on Sunday against Baltimore. Montgomery faces a White Sox team that leads the majors in average (.297), on-base percentage (.376), slugging (.486) and OPS (.862) against lefties this season. In addition, Chicago is 5-1 in its last six games on the road. 

Featured Game | New York Yankees vs. Chicago White Sox

How to make MLB predictions, parlays for Friday, May 21

The model has locked in three other MLB best bets, including one on a big underdog. You can see the best bets only at SportsLine.

So which MLB picks should you make on Friday for a shot at a big return of more than 20-1? And which surprising underdog do you need to be all over? Visit SportsLine now to see Friday’s top MLB picks, all from the projection model off to a fast start in 2021, and find out. 

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