Barring a rare tie, either the Philadelphia Eagles or San Francisco 49ers will start the 2021 NFL season with a 2-0 record. The two NFC clubs will meet on Sunday at Lincoln Financial Field with undefeated records on the line. The Eagles opened with a dominating 32-6 rout of the Falcons in Atlanta. The game made 40-year-old coach Nick Sirianni, who served as the offensive coordinator for the Colts for the last three seasons, a winner in his head coaching debut. The 49ers kicked off the season with a 41-33 road victory over the Detroit Lions. San Francisco, which played with several players who missed significant time last season because of injury, was up by 28 points before pulling its starters in the second half.
Kickoff is at 1 p.m. ET. San Francisco is a three-point favorite in the latest 49ers vs. Eagles odds from Caesars Sportsbook while the over/under for total points scored is 49.5. Before you lock in any Eagles vs. 49ers picks and predictions, make sure to check out what the SportsLine Computer Projection Model has to say.
The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 2 of the 2021 season on an incredible 121-79 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has zeroed in on 49ers vs. Eagles and locked in another confident against-the-spread pick. You can only see the model’s 49ers vs. Eagles pick at SportsLine. Here are several NFL Week 2 odds and betting lines for Eagles vs. 49ers:
- Eagles vs. 49ers spread: San Francisco -3
- Eagles vs. 49ers Over-Under: 49.5 points
- Eagles vs. 49ers money line: San Francisco -160, Philadelphia +140
- SF: WR Deebo Samuel ranked second in the NFL in receiving yards (189) after Week 1
- PHI: DT Jason Hargrave was tied for second in the league in sacks (two) after Week 1
Featured Game | Philadelphia Eagles vs. San Francisco 49ers
Why the 49ers can cover
The Niners’ offense is coming off one of its best performances in a while. The 49ers scored 31 points in the first half against the Lions last Sunday, the most points they’ve scored in a first half since putting up 35 against the Rams in 2008.
One of the reasons for the offense’s success is receiver Deebo Samuel. A 25-year-old wideout from South Carolina, Samuel had a career-high 189 receiving yards and a touchdown on nine catches against Detroit. Of the 189 yards, 109 came after the catch. That was the most yards after catch among receivers in Week 1 and 48 more than the next best receiver, Jarvis Landry.
Why the Eagles can cover
Jalen Hurts is coming off his best passing performance as a pro. In the win over the Falcons, the second-year quarterback had a passer rating of 126.4 after going 27-of-35 for 264 yards and three touchdowns. That’s the highest passer rating by an Eagle since Carson Wentz had a 128.3 rating in Week 5 of 2017.
In addition, Philadelphia has an all-purpose threat in Miles Sanders. The third-year running back from Penn State led the Eagles with 113 scrimmage yards (74 rush, 39 receiving) last week. He is tied for the third most scrimmage yards per touch among running backs since 2019 (minimum 300 touches), behind only Austin Ekeler (6.2) and Christian McCaffrey (6.0).
How to make 49ers vs. Eagles picks
Now, the model has broken down Eagles vs. 49ers from every angle. The model is leaning under on the point total, but it also says one side of the Eagles vs. 49ers spread has all the value. You can only see the model’s pick at SportsLine.
So who wins 49ers vs. Eagles? And what side on the spread has all of the value? Visit SportsLine now to see which side of the Eagles vs. 49ers spread you should jump on, all from the advanced model that is up almost $7,900, and find out.