Wednesday, December 8, 2021

Sunday Night Football odds, spread, line: 49ers vs. Colts picks, predictions from expert on 15-6 roll

Teams desperate to crawl back into their respective divisional races will meet when the Indianapolis Colts take on the San Francisco 49ers in a key Sunday Night Football matchup. The Colts (2-4), who trail the first-place Tennessee Titans by two games in the AFC South, have won two of three following an 0-3 start. The 49ers (2-3), who are third in the NFC West, trail the first-place Arizona Cardinals by 3.5 games. San Francisco has lost three in a row.

Kickoff from Levi’s Stadium in Santa Clara, Calif., is set for 8:20 p.m. ET. San Francisco is a 3.5-point favorite in the latest 49ers vs. Colts odds from Caesars Sportsbook, while the over-under for total points scored is 42. Before you make your Colts vs. 49ers picks or any other NFL predictions, you need to see what San Francisco expert Tom Fornelli has to say. 

The CBS national writer went a profitable 31-22 last season on his NFL best bets. What’s more, he has demonstrated a particularly sharp eye for the 49ers. In fact, Fornelli has gone a stunning 15-6 on picks involving San Francisco, returning more than $850 to $100 players. Anyone who has followed him is way up.

Now, Fornelli has zoned in on Colts vs. 49ers and just released his NFL picks and predictions. You can head to SportsLine now to see his picks. Here are the NFL lines and trends for Colts vs. 49ers:

  • 49ers vs. Colts spread: San Francisco -3.5
  • 49ers vs. Colts over-under: 42
  • 49ers vs. Colts money line: Indianapolis +160, San Francisco -190
  • IND: Colts are 4-2 against the spread this season
  • SF: Over is 4-0 in the 49ers’ last four games following an ATS loss

Featured Game | San Francisco 49ers vs. Indianapolis Colts

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Why the 49ers can cover

Quarterback Jimmy Garoppolo is questionable and was limited at practice with a calf injury, but indications are he will be ready by Sunday Night Football. He missed the team’s Oct. 3 game against Arizona. Garoppolo has an 85 or better rating in three of his four starts this season. He will be looking for his fifth game in a row in 2021 with a touchdown pass, and is also looking for his third game in a row against an AFC South opponent with a 100 or better rating. For the season, he has completed 78-of-118 passes (66.1 percent) for 925 yards and five touchdowns. He has been intercepted twice, but has a rating of 96.9.

Wide receiver Deebo Samuel is the 49ers’ top receiver with 31 catches for 548 yards (17.7 average) and three touchdowns. He has eight explosive plays of 20 or more yards and has converted 20 first downs. Samuel had 71 yards from scrimmage, including his fourth career rushing touchdown in Week 5 against Arizona. He has five or more catches in four of five games this season. 

Why the Colts can cover 

Despite that, San Francisco is not a lock to cover the Colts vs. 49ers spread. That’s because Indianapolis has played well of late, including Sunday’s 31-3 victory over the Houston Texans. Quarterback Carson Wentz led the charge, passing for 223 yards and two touchdowns for a 127.7 rating last week. He has six touchdowns and no interceptions for a 123.4 rating over the past three games, the highest rating in the NFL since Week 4. He has four touchdowns, including three passing and one rushing, against two interceptions in two career starts against the 49ers, both wins.

Running back Jonathan Taylor continues to tear up opposing defenses. He had 158 yards from scrimmage, including a season-high 145 yards rushing, and two touchdowns last week, his fourth-career game with 150 yards from scrimmage. That is tied for the third-most among running backs since 2020. Taylor also will be looking for his fourth game in a row with 100 or more yards from scrimmage and a rushing touchdown. He ranks second in the league with 682 yards from scrimmage in 2021, including 472 yards rushing.

How to make Colts vs. 49ers picks

For Sunday Night Football, Fornelli is leaning over on the point total, but he also says a critical X-factor makes one side of the spread a must-back. Fornelli is only sharing his 49ers vs. Colts picks at SportsLine. 

So who wins Colts vs. 49ers on Sunday Night Football? And what critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Colts vs. 49ers spread you need to jump on, all from the expert who returned more than $850 to $100 players in the last 21 San Francisco games, and find out.

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