Saturday, May 21, 2022

Padres vs. Giants odds, line, prediction: 2022 MLB picks, April 12 best bets from proven computer model

NL West rivals collide when the San Diego Padres (4-1) go on the road to face off against the San Francisco Giants (2-2) on Tuesday night. After dropping the first game of the season, San Diego has won four straight, including a 4-2 victory over the Giants on Monday. On the other side, San Francisco is looking to pick up a win against its division foe and even the series 1-1. 

First pitch is set for 9:45 p.m. ET. San Francisco is a -115 favorite (risk $115 to win $100) on the money line in the latest Padres vs. Giants odds from Caesars Sportsbook, while the over-under for total runs scored is 7.5. Before making any Giants vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every game 10,000 times, enters Week 2 of the 2022 MLB season on a 216-181 roll on top-rated MLB picks that dates back to last season, returning over $900 for $100 players. Anyone following it has seen huge returns.

Now, the model has dialed in on Padres vs. Giants and revealed its predictions and best bets. You can visit SportsLine now to see the model’s MLB picks. Here are the MLB odds and betting trends for Giants vs. Padres:

  • Padres vs. Giants moneyline: San Francisco -115, San Diego -105
  • Padres vs. Giants run-line: San Diego -1.5 (+145)
  • Padres vs. Giants over-under: 7.5 runs
  • SD: The Padres are 4-0 in their last 4 road games
  • SF: The Giants are 4-1 in their last 5 Tuesday games

Featured Game | San Francisco Giants vs. San Diego Padres

Powered by Caesars Sportsbook

Why you should back the Padres

San Diego has played fairly well on the offensive end thus far. Through five games, the Padres are ranked 10th in the league in batting average (.256), fourth in on-base percentage (.350) and have batted in 21 runs thus far. They have scored 4-plus runs in three straight games. First baseman Eric Hosmer has started the season off well. 

The four-time Gold Glove winner has a sweet left-handed stroke. He has home run power but is also patient at the plate. Hosmer is a very good athlete and defender, displaying his all-around ability. The Florida native has recorded 2-plus hits in three straight games and has a batting average of .533.  

Why you should back the Giants

First baseman Brandon Belt has a calming presence in the batters’ box. Belt brings a good approach to the plate, using patience but having plenty of home run power. His swing is smooth and can also play left field if needed. Belt has a batting average of .417 with one home run and one RBI. 

The Giants have been solid on the pitching mound. San Francisco ranks 10th in the league in ERA (3.16) and has struck out 40 total batters. They haven’t allowed 4-plus runs in three straight games. Right-hander Alex Cobb is making the start for the Giants. Cobb’s fastball was hitting 97 MPH during the spring. The Massachusetts native is a consistent strike-thrower who produces many ground ball outs. 

How to make Giants vs. Padres picks

SportsLine’s model is leaning over on the run total, as the simulations have the teams combining for eight runs. It also says one side of the money line has all the value. You can only get the model’s Giants vs. Padres pick at SportsLine.

So who wins Padres vs. Giants? And which side of the money line has all the value? Visit SportsLine now to see which side of the Giants vs. Padres money line to jump on, all from the advanced model that has returned over $900 on top-rated MLB money-line picks dating back to last season, and find out.

Related articles



Please enter your comment!
Please enter your name here

Share article

Latest articles


Subscribe to stay updated.