A huge American League East rivalry continues and a key National League matchup kicks off as part of a packed Friday night MLB schedule. The Yankees continued their recent mastery of the Red Sox with a 6-5 victory Thursday, their ninth win in the past 11 meetings. Left-hander Nestor Cortes is scheduled to take the mound in the second game of the four-game AL East showdown. Meanwhile, the Cardinals host the Phillies in a matchup of NL teams fighting to close in on the division leaders. Zack Wheeler is slated to start for Philadelphia opposite the Cardinals’ Adam Wainwright, the same pitchers who started last week’s Sunday Night Baseball matchup, won by the Phillies 4-0.
In other notable games Friday, the Mariners seek a sixth straight win as they host the Blue Jays (10:10 p.m. ET), and the Giants visit the Padres (9:40 p.m. ET). New York is the -160 favorite in the latest Red Sox vs. Yankees odds from Caesars Sportsbook, while Boston is a +135 underdog for the 7:10 p.m. ET first pitch. The 15-game MLB schedule means bettors have tons of options, and combining your top picks into a parlay can really pay off. So before you make any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine’s proven computer model.
The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 271-232 on top-rated MLB money-line picks since the start of the 2021 season, returning well over $500 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.
Now, the model has locked in four confident MLB best bets for Friday. The parlay doesn’t start until 8:10 p.m. ET, giving you plenty of time to make your MLB picks. If you successfully parlay the picks, you’d be looking at a payout of well over 16-1. You can see the model’s MLB picks for Friday only at SportsLine.
Top MLB picks today
One pick the SportsLine Projection Model is backing Friday is the Brewers (-220) to beat the Pirates (8:10 p.m. ET). This isn’t a great matchup of starting pitchers, with the Pirates expected to send out JT Brubaker (2-7, 4.28 ERA) against Milwaukee’s Aaron Ashby (1-6, 4.60 ERA). That means the Brewers should have the advantage, as they have superior hitters and a better bullpen. Milwaukee scores an average of almost a full run more per game (4.6-3.7).
Pittsburgh also has MLB’s second-worst bullpen ERA and third-worst WHIP, while the Brewers are above average in both (3.51, 1.21). Pirates relievers allowed 12 runs in three innings of a 16-0 Wednesday loss to the Yankees. Pittsburgh then played a Thursday doubleheader vs. the Reds, so the arms will be spent. Milwaukee has the fourth-most homers in MLB with 116, led by Rowdy Tellez (17) and Willy Adames (16), and it is 8-2 against Pittsburgh this year.
Featured Game | Milwaukee Brewers vs. Pittsburgh Pirates
How to make Friday MLB parlays
The model has locked in three other best bets for Friday, all of them underdogs that can help you to a massive payday. You can only see the model’s MLB parlay picks and best bets for Friday at SportsLine.
Which MLB picks should you target for Friday in a parlay offering a payout of more than 16-1? And which underdogs with excellent value are must-backs? Visit SportsLine now to see the MLB best bets for Friday from the model that is 271-232 on top-rated MLB money-line picks since the start of the 2021 season.