NFC West rivals are set to battle with the Seattle Seahawks and the San Francisco 49ers set to face off at 4:05 p.m. ET on Sunday at Levi’s Stadium in Santa Clara. The Niners are looking to bounce back from a disappointing 19-10 Week 1 loss to the Chicago Bears, with the Seahawks are looking to build off their surprising 17-16 win over the Denver Broncos on the Monday Night Football season opener. The Seahawks lead the all-time series 30-17 and have won five of the last six meetings in this rivalry.
San Francisco is favored by 10 points in the latest 49ers vs. Seahawks odds from Caesars Sportsbook, and the over/under is set at 42.5. Before making any Seahawks vs. 49ers picks, you need to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.
The model, which simulates every NFL game 10,000 times, is up more than $7,500 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2022 NFL season on an incredible 139-98 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has set its sights on 49ers vs. Seahawks and just locked in its Week 2 NFL picks and predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for 49ers vs. Seahawks:
- 49ers vs. Seahawks spread: 49ers -10
- 49ers vs. Seahawks over/under: 42 points
- 49ers vs. Seahawks picks: See picks here
Featured Game | San Francisco 49ers vs. Seattle Seahawks
What you need to know about the 49ers
The 49ers came up short against the Chicago Bears this past Sunday, falling 19-10 in ugly conditions. Quarterback Trey Lance turned in an up-and-down performance in Week 1 throwing for 164 yards and an interception while completing less than 50% of his passes in a steady rain storm. He was also the team’s leading rusher, tallying 54 yards on 13 carries.
Pro Bowl wide receiver Deebo Samuel had a relatively quiet afternoon against Chicago, rushing for 52 yards and a touchdown on eight carries, and catching two passes for 12 yards. With Elijah Mitchell (knee) out indefinitely and George Kittle (groin) listed as questionable, the 49ers will likely lean on Samuel to take a lot of the pressure off Lance going forward.
What you need to know about the Seahawks
It was a tight game that could have gone either way, but Seattle made off with a 17-16 win over the Denver Broncos last week. The Seattle offense checked out after the first half but had enough points banked to take the matchup anyway. Quarterback Geno Smith was was nearly perfect in the first half completing 17 of 18 passes for 164 yards and two touchdowns before intermission.
Seattle will have to deal with a massive blow on the defensive side of the ball with All-Pro safety Jamal Adams suffering a season-ending quad injury against the Broncos. Seattle outside linebacker Uchenna Nwosu was named NFC Defensive Player of the Week after recording a sack, seven tackles, a forced fumble, and a pass defended.
How to make 49ers vs. Seahawks picks
The model has simulated 49ers vs. Seahawks 10,000 times and the results are in. The model is leaning Under on the total, and it’s also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the model’s pick at SportsLine.
So who wins Seahawks vs. 49ers? And which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the 49ers vs. Seahawks spread to jump on, all from the advanced model that is up nearly $7,500 on its NFL picks since 2017, and find out.