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Week 2 NFL picks, odds, 2022 best bets from advanced model: This five-way football parlay pays 25-1

Cowboys quarterback Cooper Rush will make his second career start when the Dallas Cowboys face the Cincinnati Bengals on Sunday. A 28-year-old backup, Rush won the only start of his career, a 20-16 victory over the Vikings in Week 8 of last season. On Sunday, Rush will fill in for Dak Prescott, who is out multiple weeks with a broken right thumb. Cincinnati is favored by seven points in the latest NFL odds from Caesars Sportsbook, but which side should you back with your NFL bets? The game is one of 16 on a loaded Week 2 NFL schedule. Other key NFL matchups include the Bears facing their nemesis, Packers quarterback Aaron Rodgers, and the Bills and Titans colliding in one of two Monday Night Football games. Before you make any Week 2 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up more than $7,500 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2022 NFL season on an incredible 139-98 run on top-rated NFL picks that dates back to the 2017 season.  

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 2. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 2 NFL picks at SportsLine

Top Week 2 NFL picks

After simulating every game 10,000 times, the model is high on the Cleveland Browns to win and cover against the New York Jets. The Browns (1-0) got their season off to a winning start with a 26-24 victory over former Cleveland quarterback Baker Mayfield and the Carolina Panthers. Meanwhile, the Jets (0-1) have lost three straight games and six of their last seven dating to last season.

The Browns have a dynamic running back duo in Nick Chubb and Kareem Hunt. Last week, Chubb ran for 141 yards and Hunt had 70 yards from scrimmage and two touchdowns. They helped the team run for 217 yards, second most by any team in Week 1. See which other NFL parlay picks to make here.

How to make Week 2 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including an underdog that wins outright. You can only see the model’s NFL Week 2 best bets and parlay at SportsLine

What are the model’s top Week 2 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 2 NFL best bets from a model on a 139-98 run on its top-rated picks, and find out.

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