The Buffalo Bills (1-0) will kick off their 2022 home opener with a primetime battle in the first game of a Monday Night Football doubleheader against the Tennessee Titans (0-1) that wraps up the Week 2 NFL schedule. Buffalo had a dominant performance in Week 1, topping the Los Angeles Rams, 31-10. Meanwhile, Tennessee gave up a 13-point lead and fell to the New York Giants 21-20 in Week 1.
Kickoff from Highmark Stadium in Orchard Park, N.Y., is set for 7:15 p.m. ET. Buffalo is favored by 10 points in the latest Bills vs. Titans odds from Caesars Sportsbook, and the over/under is set at 48. Before making any Titans vs. Bills picks, you need to see the NFL predictions and betting advice from SportsLine’s advanced computer simulation model.
The model, which simulates every NFL game 10,000 times, is up more than $7,500 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2022 NFL season on an incredible 139-98 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has set its sights on Bills vs. Titans and just locked in its picks and NFL predictions. You can head to SportsLine now to see the model’s picks. Now, here are several NFL odds and betting lines for Titans vs. Bills:
- Bills vs. Titans spread: Buffalo -10
- Bills vs. Titans over/under: 48 points
- Bills vs. Titans money line: Tennessee +360, Buffalo -480
- TEN: Titans are 8-2 ATS in their last 10 Monday games
- BUF: Bills are 3-0-1 ATS in their last four home games
- Bills vs. Titans picks: See picks here
Featured Game | Buffalo Bills vs. Tennessee Titans
Why the Bills can cover
Buffalo had a commanding contest in the Week 1 win over the Rams. The offense had plenty of success with playmakers all across the field. Quarterback Josh Allen is a dominant presence and started the season off well with 297 yards and three passing touchdowns. He also led the team with 56 rushing yards. The Bills moved the ball well, finishing with 413 total yards of offense.
Buffalo played suffocating defense and made life extremely difficult for the Rams’ offense. The Bills held Los Angeles to 243 yards with 3.7 yards per play. The defensive line consistently caused havoc, recording seven sacks. Von Miller made an immediate impact for Buffalo, logging four total tackles, two sacks and three tackles for loss.
Why the Titans can cover
Quarterback Ryan Tannehill is an athletic playmaker under center for Tennessee. Tannehill is patient in the pocket with a solid arm and good accuracy. The Texas A&M product played well in the Week 1 loss to the New York Giants, going 20 of 33 for 266 yards and two touchdowns. He pushed the ball downfield, completing seven passes of 20-plus yards.
Running back Derrick Henry is a tank in the backfield. Once Henry gets to the second level of the defense, it’s extremely difficult to bring him down. The two-time Pro Bowl selection has strong vision with breakaway speed. The Alabama product owns the strength to be a constant powerhouse. Last week, he had 21 carries for 82 yards.
How to make Bills vs. Titans picks
SportsLine’s model is leaning Over on the total, with the teams projected to combine for 52 points. The model also says one side of the spread has all the value. You can only see the model’s MNF pick at SportsLine.
So who wins Titans vs. Bills on Monday Night Football? And which side of the spread has all the value? Visit SportsLine now to see which side of the Titans vs. Bills spread you need to jump on Monday, all from the model that has crushed its NFL picks, and find out.