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Week 6 NFL picks, odds, 2022 best bets from advanced model: This five-way football parlay would pay 25-1

Joe Burrow and Ja’Marr Chase will return to the scene of their top achievement to date when the Cincinnati Bengals visit the New Orleans Saints during the Week 6 NFL schedule. In the final game of their collegiate careers, Burrow and Chase helped lead LSU to a 42-25 victory over Clemson at the Superdome in New Orleans, which gave the Tigers their fourth national championship in program history. Burrow threw for 463 yards and five touchdowns, while Chase amassed 221 yards on nine catches, including two for scores. The Bengals are 1.5-point favorites against the Saints in the latest Week 6 NFL odds at Caesars Sportsbook. Which Week 6 NFL lines should you target with your Week 6 NFL bets? Before you make any Week 6 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2022 NFL season on an incredible 146-106 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 6. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 6 NFL picks at SportsLine.

Top Week 6 NFL picks

After simulating every game 10,000 times, the model is high on the New York Giants (+5.5) to cover against the Baltimore Ravens on Sunday. The Giants recorded just four wins for the second time in three seasons in 2021, but already have matched that total in Brian Daboll’s first year as head coach. One reason for their success has been the play of running back Saquon Barkley, who is second in the NFL with 533 rushing yards and leads the league with 676 yards from scrimmage.

The Ravens have been fortunate to split their last two games, as Lamar Jackson has underperformed following a strong start to the year. The 2019 NFL MVP has thrown just two TD passes and three interceptions over those two contests, failing to reach 175 passing yards in each after making at least three scoring tosses with only two picks in his first three outings of the season. That is one reason the Giants are covering the spread in over 50% of simulations. See which other NFL parlay picks to make here.

How to make Week 6 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing a total that is off by a full touchdown. You can only see the model’s NFL Week 6 best bets and parlay at SportsLine

What are the model’s top Week 6 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 6 NFL best bets from a model on a 146-106 run on its top-rated picks, and find out.

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