Clemson vs. Syracuse odds, line: 2021 college football picks, Week 7 predictions from model on 19-7 run


The ACC grabs the spotlight in the college football world with an interesting matchup on Friday evening. The Clemson Tigers visit the Syracuse Orange in a battle between ACC Atlantic rivals. Clemson is a disappointing 3-2 this season, though the Tigers are 2-1 in conference play. Syracuse is 3-3 overall and 0-2 against ACC foes.

Kickoff is at 7 p.m. ET at Carrier Dome. Caesars Sportsbook lists the Tigers as 13.5-point road favorites, while the over-under, or total number of points Vegas thinks will be scored, is 44.5 in the latest Clemson vs. Syracuse odds. Before making any Syracuse vs. Clemson picks, be sure to see the college football predictions and betting advice from the proven SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,800 for $100 players on its top-rated college football picks against the spread. It also enters Week 7 of the 2021 season on a 19-7 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Clemson vs. Syracuse and just released its picks and predictions. You can head to SportsLine to see the model’s CFB picks. Now, here are several college football odds and betting lines for Syracuse vs. Clemson:

  • Clemson vs. Syracuse spread: Clemson -13.5
  • Clemson vs. Syracuse over-under: 44.5 points 
  • Clemson vs. Syracuse money line: Clemson -600, Syracuse +425
  • CLEM: The Tigers are 0-5 against the spread this season 
  • SYR: The Orange are 5-1 against the spread in 2021

Featured Game | Syracuse Orange vs. Clemson Tigers

Why Clemson can cover

Despite offensive challenges and uneven results, Clemson’s defense remains one of the best in the country. The Tigers lead the ACC in scoring defense, allowing only 12.2 points per game, and Clemson is No. 2 in total defense, yielding only 306.4 total yards per game. Clemson is a top-five passing defense, allowing 203.8 yards per game and an ACC-leading 5.8 yards per attempt. Opponents are completing only 60.8 percent of passes against Clemson, with more interceptions (five) than touchdown passes (four) in 2021. 

On the ground, the Tigers will need to be strong against a potent Syracuse rushing attack, and Clemson leads the ACC in giving up only 2.7 yards per carry and only one rushing touchdown. Given that Syracuse is dead-last in the ACC in passing yardage (169.2 per game), Clemson can key on the run, and the Orange are also the worst team in the ACC on third down, moving the chains only 35.1 percent of the time this season.

Why Syracuse can cover

The Orange have been excellent in the running game offensively, leading the ACC in rushing yards, yards per carry and rushing touchdowns to this point. With that said, this matchup against Clemson is even more favorable for Syracuse’s defense, which has been strong this season. Syracuse ranks No. 3 in the ACC in total defense, giving up 308.2 yards per game, and the Orange rank in the top four in both passing defense (194.2 yards per game) and rushing defense (114.0 yards per game). Syracuse leads the ACC with 22 sacks, and the Orange are also No. 3 in yards per carry, giving up 3.1 yards per tote. 

Syracuse can also take full advantage of a Clemson offense that is struggling mightily, as the Tigers are currently dead-last in the ACC in scoring offense (21.2), total offense (324 yards per game), yards per pass attempt (5.7) and completion percentage (54.8 percent).

How to make Clemson vs. Syracuse picks

SportsLine’s model is leaning under on the total, projecting the teams to combine for 42 points. The model also says one side of the spread hits in well over 50 percent of simulations. You can only get the model’s Syracuse vs. Clemson ATS pick at SportsLine.  

So who wins Clemson vs. Syracuse? And which side of the spread hits in well over 50 percent of simulations? Visit SportsLine now to find out which side of the Clemson vs. Syracuse spread you need to jump on Friday, all from the model that has crushed its college football picks, and find out.  





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