College football odds, lines, picks, bets, predictions for Week 4, 2021: Proven simulation backing LSU, UCLA

No. 7 Texas A&M and No. 16 Arkansas reignite their rivalry Saturday at 3:30 p.m. ET on CBS in their annual game at AT&T Stadium in Arlington, Texas. A&M is favored by 5.5 points in the latest Week 4 college football odds from Caesars Sportsbook. The Aggies have won the previous nine editions of this rivalry game, with three of those wins coming in overtime. The top-five teams in the AP Top 25, meanwhile, are each favored by double digits in the Week 4 college football schedule, with four of those squads favored by more than 20 points at Caesars. 

No. 1 Alabama is -45 against Southern Miss, No. 2 Georgia is favored by 35.5 at Vanderbilt, No. 3 Oregon is favored by 28.5 against Arizona, No. 4 Oklahoma is favored by 17 against West Virginia and No. 5 Iowa is -23 against Colorado State. Before making any Week 4 college football picks on those games or others, be sure to see the latest college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 4 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 4 college football predictions

One of the top college football picks the model is recommending for Week 4: LSU covers as a 2.5-point favorite against Mississippi State at noon ET on Saturday. Both teams enter at 2-1, with LSU dropping a game at UCLA before beating McNeese State and Central Michigan, while MSU beat Louisiana Tech and NC State before losing to Memphis.

In the first conference game for each team, LSU gets the chance to prove that its 38-27 loss to UCLA was a fluke. The Tigers have figured some things out against inferior competition in the past two weeks, and now they have the benefit of facing Mississippi State’s offense with the knowledge that the strategy it employed last year — blitz all the time — did not work against Mike Leach’s Air Raid offense. 

In simulations from SportsLine’s model, LSU wins and covers 60 percent of the time. The point total, which sits at 56.5 according to Caesars, goes under in well over 50 percent of simulations.

Another one of the college football predictions from the model: No. 24 UCLA (-5) covers at Stanford. The Bruins got off to a nice start this season when they picked up wins over Hawaii and No. 16 LSU, but they slipped up in a loss to Fresno State last week. They are going to be motivated for a bounce-back performance at Stanford on Saturday. UCLA quarterback Dorian Thompson-Robinson has completed 55 percent of his pass attempts and has a 7-to-1 touchdown-to-interception ratio this season.

Stanford has played three straight games away from home to open the season, which could lead to some fatigue entering this contest. The Bruins have covered the spread in six of their last nine games and they are 4-2 ATS in their last six conference matchups. SportsLine’s model has UCLA covering this spread in almost 60 percent of simulations. 

How to make Week 4 college football picks 

The model has also made the call on who wins and covers in every other game on the Week 4 college football schedule, and it’s calling for a Top 25 favorite to go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which Top 25 favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,000 in profit over the past five-plus seasons, and find out.

Week 4 college football odds (via Caesars)

Here are the college football lines for some of Week 4’s most notable matchups:

Saturday, Sept. 25

Georgia vs. Vanderbilt (+34, 51)

Notre Dame vs. Wisconsin (-5.5, 46.5)

Featured Game | Wisconsin Badgers vs. Notre Dame Fighting Irish

UMass vs. Coastal Carolina (-36, 67)

Rutgers vs. Michigan (-18.5, 51.5)

Clemson vs. NC State (+10, 47)

Featured Game | NC State Wolfpack vs. Clemson Tigers

Iowa State vs. Baylor (+6.5, 47.5)

Featured Game | Baylor Bears vs. Iowa State Cyclones

Colorado State vs. Iowa (-23, 44.5)

Featured Game | Iowa Hawkeyes vs. Colorado State Rams

Texas A&M vs. Arkansas (+5.5, 48)

Featured Game | Arkansas Razorbacks vs. Texas A&M Aggies

Georgia State vs. Auburn (-27, 57)

Featured Game | Arkansas Razorbacks vs. Texas A&M Aggies

UCLA vs. Stanford (+6, 58.5)

Featured Game | Stanford Cardinal vs. UCLA Bruins

Nebraska vs. Michigan State (-5, 51.5)

Featured Game | Michigan State Spartans vs. Nebraska Cornhuskers

Kansas State vs. Oklahoma State (-6, 45)

Featured Game | Oklahoma State Cowboys vs. Kansas State Wildcats

North Carolina vs. Georgia Tech (+12, 63)

Featured Game | Georgia Tech Yellow Jackets vs. North Carolina Tar Heels

Akron vs. Ohio State (-49, 67.5)

Alabama vs. Southern Mississippi (+45, 57.5)

Oklahoma vs. West Virginia (+16.5, 59)

Featured Game | Oklahoma Sooners vs. West Virginia Mountaineers

USF vs. BYU (-23, 52)

Featured Game | BYU Cougars vs. South Florida Bulls

Arizona vs. Oregon (-28, 58)

Featured Game | Oregon Ducks vs. Arizona Wildcats

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