Cowboys vs. Giants odds, spread, line, predictions: 2021 NFL picks, Week 5 best bets from model on 124-82 run


The New York Giants look to win their second game in a row after posting a stunning upset a week ago when they meet the Dallas Cowboys in an NFC East showdown on Sunday. The Giants (1-3), who were coming off a pair of narrow losses, rebounded by holding off New Orleans 27-21 in the Saints‘ first home game after Hurricane Ida. The Cowboys (3-1), meanwhile, have won three straight after losing the season opener at Tampa Bay. Dallas is looking to post its first winning season since going 10-6 in 2018.

Kickoff from AT&T Stadium in Arlington, Texas, is set for 4:25 p.m. ET. Dallas is a seven-point favorite in the latest Cowboys vs. Giants odds from Caesars Sportsbook, while the over-under for total points scored is 52.5. Before you make any Giants vs. Cowboys picks or predictions, make sure to check out the NFL analysis and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 5 of the 2021 season on an incredible 124-82 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated Cowboys vs. Giants 10,000 times and just revealed its NFL expert picks and predictions. You can head to SportsLine now to see the model’s picks. Here are several Week 5 NFL odds and betting lines for Giants vs. Cowboys:

  • Cowboys vs. Giants spread: Cowboys -7
  • Cowboys vs. Giants over-under: 52.5 points
  • Cowboys vs. Giants money line: New York +260, Dallas -330 
  • NYG: The Giants are 5-0 against the spread in their last five games against NFC East opponents 
  • DAL: The Cowboys have covered four straight games

Featured Game | Dallas Cowboys vs. New York Giants

Why the Cowboys can cover

Dallas has one of the deepest receiving corps in the league, led by wide receiver CeeDee Lamb. He has 20 receptions for 264 yards (13.2 average) and one touchdown. He has five explosive plays of 20 or more yards, 121 yards after the catch and has converted 13 first downs. In the season-opener at Tampa Bay, Lamb caught seven passes for 104 yards (14.9 average) and one touchdown. In his last home game against the Giants, Lamb caught eight passes for a career-high 124 yards.

Another receiver tearing up opposing defenses is Amari Cooper. He had a team-high 69 receiving yards and caught his third touchdown pass of the season last week. He has four or more receptions in four of his five career games against the Giants. For the year, Cooper has 22 receptions for 258 yards (11.7 average) and three touchdowns. He has four explosive plays and 15 first down conversions.

Why the Giants can cover 

New York wide receiver Kenny Golladay is off to a solid start to the season and leads the team with 282 receiving yards. He has 17 receptions with three explosive plays of 20 yards or more with 15 first-down conversions. Golladay had six receptions for a team-high 116 yards in Week 4. It was his 11th career 100-yard game. He has 60 or more receiving yards in three of four games this season.

Defensively, the Giants are led by cornerback Logan Ryan, who has a team-high 35 tackles, including 20 solo. He has one tackle for loss with two pass breakups, one forced fumble and one fumble recovery. Last week against the Saints, Ryan had nine tackles and a pass breakup. He will be looking for his third game in a row with a pass breakup and fifth in a row with seven or more tackles.

How to make Cowboys vs. Giants picks

SportsLine’s model is leaning over on the point total, projecting the teams to combine for 54 points. In fact, it says New York’s Daniel Jones will throw for 250 yards passing and two touchdowns, while Dallas quarterback Dak Prescott throws for nearly 300 yards and two scores. It also says one side of the spread cashes in over 50 percent of simulations. You can only get the model’s Cowboys vs. Giants picks at SportsLine.

So who wins Giants vs. Cowboys? And which side of the spread hits in over 50 percent of simulations? Visit SportsLine now to see which side of the Giants vs. Cowboys spread to jump on, all from the advanced model that is up nearly $7,900 on its NFL picks since, and find out.





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