Iowa State vs. Oklahoma State odds, line: 2021 college football picks, Week 8 predictions from proven model

Iowa State still has a chance to get into the Big 12 championship picture, but to do that, the Cyclones need a win at Jack Trice Stadium on Saturday against No. 8 Oklahoma State at 3:30 p.m. ET. Iowa State is looking for its third consecutive win after victories over Kansas and Kansas State, while the Cowboys are coming off of a come-from-behind victory against Texas in Austin last weekend. Iowa State is 4-2 overall and 2-1 at home, while the Cowboys are 6-0 overall and 2-0 on the road. 

The Cyclones have lost their last four games against the Cowboys in Ames, but are favored by seven points in the latest Iowa State vs. Oklahoma State odds from Caesars Sportsbook, and the over-under is set at 47. Iowa State is 4-0 overall as a home favorite this season, but just 2-2 against the spread. Before entering any Oklahoma State vs. Iowa State picks, you’ll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 8 of the 2021 season on a 22-9 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Iowa State vs. Oklahoma State. You can head to SportsLine to see its picks. Here are several college football odds for Oklahoma State vs. Iowa State:

  • Iowa State vs. Oklahoma State spread: Iowa State -7
  • Iowa State vs. Oklahoma State over-under: 47 points
  • Iowa State vs. Oklahoma State money line: Cyclones -270, Cowboys +220

Featured Game | Iowa State Cyclones vs. Oklahoma State Cowboys

What you need to know about Iowa State

Cyclones running back Breece Hall led the effort on offense last weekend against Kansas State in a big 33-20 win. The junior finished with two touchdowns and 197 yards on 30 carries. One of the most memorable plays of the contest was Hall’s 75-yard touchdown rush in the first quarter. Things shouldn’t be quite as easy this week against the Cowboys, who have a top-20 rushing defense and have only allowed 2.99 yards per carry this season.

Senior QB Brock Purdy has been steady again this season, and though he hasn’t been putting up eye-popping passing numbers, he has completed nearly 75-percent of his passes. His top target has been senior receiver Xavier Hutchinson, who has 34 catches for 414 yards and three touchdowns in 2021. Oklahoma State has been stingy against the pass as well, so someone will need to step up on offense for the Cyclones.

What you need to know about Oklahoma State

The Cowboys have a pretty good running back of their own in Jaylen Warren, who was the key player on offense in last weekend’s win against the Longhorns. The redshirt senior picked up 193 yards on the ground on 33 carries in the 32-24 win. Head coach Mike Gundy needs Warren to be on top of his game because quarterback Spencer Sanders has not been. Over the last two games, Sanders has completed just 58 percent of his passes with two touchdowns and four interceptions.

On defense, the Cowboys have a couple of players that have been difference-makers this season. Senior safety Kolby Harvell-Peel has two interceptions so far this season and senior linebacker Malcolm Rodriguez has two forced fumbles. Oklahoma State has been one of the nation’s best defenses at getting off the field on third downs, and have only allowed opponents to convert less that 29-percent of them.

How to make Oklahoma State vs. Iowa State picks

The model is leaning under on the total, and it’s also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Iowa State vs. Oklahoma State? And which side of the spread hits well over 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks

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