White Sox vs. Pirates odds, line: 2021 MLB picks, predictions for June 23 from proven computer model

The Chicago White Sox look to right the ship after five-straight losses when they take on the Pittsburgh Pirates on Wednesday afternoon. The White Sox (43-30) currently boast a two-game lead for first place in the American League Central. The Pirates (26-45), last in the National League Central, beat Chicago in the first game of the series and are surprising winners of three of their past four games.

First pitch from the PNC Park in Pittsburgh is set for 12:35 p.m. ET. Chicago is a -160 favorite (risk $160 to win $100) on the money line in the latest White Sox vs. Pirates odds from William Hill Sportsbook, while the over-under for total runs scored is 8.5. Before making any Pirates vs. White Sox picks, check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league’s last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. It’s off to a sizzling start in 2021, going 100-74 on top-rated MLB money-line picks through 12 weeks, returning over $1,200. Anyone following it has seen huge returns.

Now, the model has dialed in on White Sox vs. Pirates. You can visit SportsLine now to see the picks. Here are the MLB lines and trends for Pirates vs. White Sox:

  • White Sox vs. Pirates money line: Chicago -160, Pittsburgh +150
  • White Sox vs. Pirates run line: Pittsburgh +1.5 (-115)
  • White Sox vs. Pirates over-under: 8.5 runs
  • CWS: The White Sox have covered 71 percent of the time when listed as road favorites.
  • PIT: The Pirates have won six of the past seven games against Chicago in PNC Park.

Featured Game | Pittsburgh Pirates vs. Chicago White Sox

Why you should back the White Sox

In spite of multiple injuries, the White Sox have boasted one of the most productive lineups in baseball all season. Led by Jose Abreu, Tim Anderson, and Yoan Moncada, Chicago has enough star power to pose a serious threat to any opposing pitcher.

So, with unproven starter Chase De Jong on the mound for the Pirates, it should come as no surprise that the White Sox are implied for one of the highest run totals of any team playing on Wednesday. De Jong’s 4.26 ERA doesn’t stand out at first glance, but that has come on just a 19-inning sample size. In 73 career innings, De Jong’s ERA sits at 6.38. And a look at his peripherals and advanced indicators for this season suggests that his 2021 ERA should be closer to that 6.38 mark. Regression could certainly be coming for De Jong while facing this potent Chicago lineup.

Why you should back the Pirates

There’s a reason the total is set for nearly nine runs in this one — the Pirates aren’t the only team with a suspect pitcher on the mound. Chicago’s Dylan Cease has shown flashes of brilliance, but there have been more downs than ups for him as of late. In four June starts, Cease has a 6.75 ERA. Opponents have been really seeing the ball well during that time, recording a 41.1 percent hard-hit rate and 16.1 percent barrel rate against Cease.

Pittsburgh’s lineup features many hard-hitting lefties who could pose a problem for the right-handed Cease, highlighted by the red-hot switch-hitting Bryan Reynolds. Reynolds enters Wednesday’s action with multiple hits in five of his past six games, and he has two home runs and seven RBIs during that span. He and lefty leadoff hitter Adam Frazier were a big part of Pittsburgh’s six-run output against Chicago ace Lucas Giolito on Tuesday, and they could make life difficult for Cease in Wednesday’s outing.

How to make Pirates vs. White Sox picks

SportsLine’s model is leaning over on the total, as the teams combine for 9.4 runs in the simulations, and it also says one side of the money line has all the value. You can only see the pick at SportsLine

So who wins White Sox vs. Pirates? And which side of the money line has all the value? Visit SportsLine now to see which side of the money line to jump on, all from the advanced model off to a hot start in 2021.

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