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Oregon vs. Arizona odds, line, spread: College football picks, Week 4 predictions from proven computer model

The Arizona Wildcats and the Oregon Ducks will face off in a Pac-12 showdown at 10:30 p.m. ET on Saturday, September 25 at Autzen Stadium. No. 3 Oregon (3-0) is riding high and enters this week with legitimate national title aspirations, while Arizona (0-3) is still looking for its first win of the 2021 college football season. 

Oregon is favored by 28 points in the latest Oregon vs. Arizona odds from Caesars Sportsbook, and the over-under for total points scored is set at 58. Before locking in any Arizona vs. Oregon picks, you need to check out the college football predictions and analysis from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Oregon vs. Arizona and just revealed its picks and predictions. You can head to SportsLine now to see its picks. Here are several college football odds and betting lines for Oregon vs. Arizona:

  • Oregon vs. Arizona spread: Oregon -28
  • Oregon vs. Arizona over-under: 58 points
  • Oregon vs. Arizona moneyline: Oregon -7000, Arizona +1600

Featured Game | Oregon Ducks vs. Arizona Wildcats

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What you need to know about Oregon

You’re bound to get a positive result if you outscore your opponent every quarter, and that’s exactly how it played out for Oregon on Saturday, with the Ducks bagging a 48-7 victory over the Stony Brook Seawolves. This week against Arizona, it will be all about avoiding a let down for Oregon in its Pac-12 opener.

The Wildcats have struggled stopping the run in 2021, and the Ducks are averaging over 209 rushing yards per game. If that trend continues, Oregon should cruise to a fairly easy victory on Saturday night.

What you need to know about Arizona

Arizona has had numerous issues on both sides of the ball this season, and enters this week coming off a loss to FCS opponent Northern Arizona. The Wildcats’ best shot at keeping this game close could be controlling the ball and keeping Oregon’s explosive offense off the field. If they fail to do so, this game could get ugly in a hurry.

How to make Oregon vs. Arizona picks

The model has simulated Oregon vs. Arizona 10,000 times and the results are in. We can tell you that the model is leaning under on the point total, and it’s also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the model’s Oregon vs. Arizona ATS pick at SportsLine.

So who wins Oregon vs. Arizona? And which side of the spread cashes in almost 60 percent of simulations?  Visit SportsLine now to see which side of the Oregon vs. Arizona spread to jump on, all from the advanced model that finished the past five-plus years up nearly $3,000 on its FBS college football picks, and find out.

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