College football odds, lines, bets, predictions for Week 5, 2021: Computer model picks Florida, Cincinnati

The Heisman Trophy co-favorites will square off Saturday afternoon on CBS when No. 1 Alabama hosts No. 12 Ole Miss as the headliner of the Week 5 college football schedule. Crimson Tide quarterback Bryce Young and Rebels signal-caller Matt Corral are atop the Heisman betting market. Alabama is listed as a 14.5-point favorite in the latest Week 5 college football odds at Caesars Sportsbook. The Crimson Tide have already had one scare this season, sneaking past Florida in a 31-29 final two weeks ago.

Another marquee SEC clash will take place earlier in the day when No. 2 Georgia faces No. 8 Arkansas at noon ET. Caesars has the Bulldogs favored by 18 points in the Week 5 college football spreads. How should you set your college football bets for those games and others? Before making any Week 5 college football picks, be sure to see the latest college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, It also enters Week 5 of the 2021 season on a 81-61 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 5 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 5 college football predictions

One of the top college football picks the model is recommending for Week 5: Florida covers (-7.5) in its trip to Kentucky on Saturday night. The Gators have covered the spread in both of their conference games so far this season and they have a chance to make it three in a row in this game. They turned on the jets in the second half of a 38-14 blowout against Tennessee last week. Kentucky is unbeaten, but its last three wins have all come by single digits.

Florida’s rushing attack averaged 7.1 yards per carry against the Vols, led by quarterback Emory Jones. He had 144 rushing yards on 15 attempts, including a 49-yard scamper. SportsLine’s model expects him to have success against Kentucky’s defense, which is why the Gators are covering this spread in over 50 percent of simulations.

Another one of the college football predictions from the model: No. 7 Cincinnati covers as a two-point favorite at No. 9 Notre Dame in a 2:30 p.m. ET kickoff on Saturday. The Bearcats are 3-0 straight up and 2-0 against the spread so far, and are challenging to be not just one of the best Group of Five teams in the nation, but one of the best teams in the nation, period. If the Bearcats wants to be considered for the College Football Playoff, this is a must-win matchup.

Cincinnati passed its first test in a 38-24 win over Indiana in Week 3, and has had a week to rest before playing a Notre Dame team coming off a physical game against Wisconsin. In SportsLine’s simulations, Cincinnati wins and covers the spread well over 50 percent of the time. In those same simulations, the point total goes under 50.5 more than 60 percent of the time.

How to make Week 5 college football picks

The model has also made the call on who wins and covers in every other game on the Week 5 college football schedule, and it’s calling for a Top 25 favorite to go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which Top 25 favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,300 in profit over the past five-plus seasons, and find out.