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Cowboys vs. Cardinals odds, spread, line: NFL picks, Week 17 prediction, best bets from model on 134-96 run

The Dallas Cowboys went on a six-game winning streak after losing their 2021 NFL season-opener, but then hit a rough patch, losing three of four contests. They’ve righted the ship since falling to Las Vegas in overtime on Thanksgiving, winning four straight contests and clinching the NFC East for the fourth time in eight years. Dallas (11-4) still can capture the No. 1 seed in the NFC playoff picture, but it first must get past the visiting Arizona Cardinals (10-5) on Sunday.

Kickoff from AT&T Stadium is set for 4:25 p.m. ET. Dallas is a six-point favorite in the latest Cowboys vs. Cardinals odds from Caesars Sportsbook, while the over-under for total points scored is 51.5. Before locking in any Cardinals vs. Cowboys picks, make sure you see the latest NFL predictions from SportsLine’s proven projection model.

The model, which simulates every NFL game 10,000 times, is up over $7,100 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 17 of the 2021 season on an incredible 134-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Cowboys vs. Cardinals. You can visit SportsLine now to see the picks. Here are the NFL odds from Caesars Sportsbook and trends for Cardinals vs. Cowboys:

  • Cowboys vs. Cardinals spread: Dallas -6
  • Cowboys vs. Cardinals over-under: 51.5 points
  • Cowboys vs. Cardinals money line: Dallas -270, Arizona +220
  • DAL: Cowboys are 7-2 against the spread in their last nine home games
  • AZ: Cardinals are 2-8 ATS in their last 10 contests against teams with winning records

Why the Cowboys can cover

Dallas’ offense leads the NFL in total yards (409.5) and scoring (30.5 points). The Cowboys have recorded at least 21 points in six of their last seven contests and have outscored their opponents 131-57 during their four-game winning streak. Their 56-point outburst in last week’s win over Washington was their highest output since they posted 59 in a Week 6 victory against San Francisco in 1980.

Quarterback Dak Prescott leads Dallas’ third-ranked passing offense (282.7 yards) and is ninth in the league in passing yards (3,928) and touchdown tosses (29). The 28-year-old matched a season-high with four TD passes against Washington after recording a total of five over his previous five games.

Why the Cardinals can cover

Arizona owns the best road record in the NFL this season at 7-1. It also has had the upper hand against the Cowboys in the all-time series, winning five of the last six meetings. The Cardinals have posted double-digit victories in their last two visits to Dallas, including a 38-10 triumph in Week 6 last season.

Quarterback Kyler Murray has thrown for at least 3,000 yards and 20 touchdowns for the third time in his three-year career despite missing three games this year with an ankle injury. The 24-year-old has completed 69.1 percent of his pass attempts for 3,284 yards with 21 TDs while running for 344 yards and five scores.

How to make Cowboys vs. Cardinals picks

SportsLine’s model is leaning over the total. In fact, it’s calling for 52 total points. It also says one side of the spread cashes nearly 60 percent of the time. You can only get the pick at SportsLine.

So who wins Cardinals vs. Cowboys on Sunday? And which side of the spread cashes almost 60 percent of the time? Visit SportsLine now to see which side of the Cardinals vs. Cowboys spread to be all over, all from the advanced model that is up more than $7,100 on its top-rated NFL picks, and find out.

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